3-Phenylpyridine → 2-Methyl-5-phenylpyridine

HRID 892221

Reaktionsgleichung

Reaktionsgleichung von HRID 892221
[C:1]1([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13][Li]>C(OCC)C>[C:1]1([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[N:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 138863-PhenylpyridineHCID 178418348HCID 178418348, Verbindung

Produkt 1

HCID 767442-Methyl-5-phenylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a cooled (−70° C.) solution of 3-phenylpyridine (1.43 mL, 10.0 mmoles) in diethyl ether (7.5 mL) is added dropwise methyllithium (LiBr complex, 1.5 M in diethyl ether, 7.33 mL, 11.0 mmoles). After letting warm to room temperature over 16 hours the reaction is cooled (0° C.) and quenched with distilled water (5 mL). The reaction is then extracted with methylene chloride, the organic layer isolated and concentrated, and the resulting residue purified by column chromatography (silica, 3:1 hexane: EtOAc) to yield the title compound as a pale yellow oil. MS(ESI) 170 (M+H)+.

Aufarbeitung

  1. temperatureis cooled (0° C.)
  2. customquenched with distilled water (5 mL)
  3. extractionThe reaction is then extracted with methylene chloride
  4. customthe organic layer isolated
  5. concentrationconcentrated
  6. customthe resulting residue purified by column chromatography (silica, 3:1 hexane: EtOAc)

Quellen und Nachweise

ORD-Eintrag
ord-9f391ccfc2a144e1b9db62899f3d1216
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US07005440B1

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