Potassium Hydroxide → 7-nitro-3,4-dihydro-2H-1,4-benzoxazin-3-one

HRID 892355

Reaktionsgleichung

Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][C:7]=1[OH:15])=[O:4].[OH-].[K+]>CS(C)=O>[N+:12]([C:9]1[CH:10]=[CH:11][C:6]2[NH:5][C:3](=[O:4])[CH2:2][O:15][C:7]=2[CH:8]=1)([O-:14])=[O:13]

Komponenten

Reaktionsbedingungen

Temperatur: 95 °C

Versuchsvorschrift

A mixture of 8 (22 g) and powdered KOH (6.9 g) in DMSO (100 ml) was stirred at 95° C. for 30 min. and poured onto crushed ice (400 g). The resulting precipitate was collected and washed with H2O to give 9 (15.7 g, 85%): mp 230°-232° C.; MS m/e 194 (M+).

Aufarbeitung

additionpoured
customThe resulting precipitate was collected
washwashed with H2O

Quellen und Nachweise

ORD-Eintrag: ord-0b33cd03661144cdbccc1cf78e75bb00
Quelldatensatz: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05118323

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