Reaktionsgleichung
[N+:1]([C:4]1[CH:21]=[CH:20][C:7]([O:8][CH2:9][C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)=[CH:6][CH:5]=1)([O-])=O.O.NN>CO.O1CCCC1.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)=[CH:20][CH:21]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 35 °C
Versuchsvorschrift
117.8 g (0.42 mol) of 2-(4-nitrophenoxymethyl)quinoline were dissolved in 1 l of methanol/tetrahydrofuran (1:1). About 5 g of Raney nickel were added and the mixture was warmed to 35° C. 63.1 g (1.26 mol) of hydrazine hydrate were then added dropwise and the mixture was stirred overnight. The residue was filtered off, the solution was concentrated in vacuo and the residue was taken up with methylene chloride. The solution was then washed with water and conc. hydrochloric acid was added to the organic phase. The precipitate which deposited was filtered off, washed with 2N hydrochloric acid and dissolved in water, and the solution was rendered alkaline with 20% strength NaOH. The residue was dried in vacuo.
Aufarbeitung
- filtrationThe residue was filtered off
- concentrationthe solution was concentrated in vacuo
- washThe solution was then washed with water and conc. hydrochloric acid
- additionwas added to the organic phase
- filtrationThe precipitate which deposited was filtered off
- washwashed with 2N hydrochloric acid
- dissolutiondissolved in water
- customThe residue was dried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-2e4cd6db82ee48a7960663130937bec4
- Quelldatensatz
- uspto-grants-1992_06
- Patentnummer
- US05120744
Verknüpfte Notizen
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