3,4-Diaminopyridine → HCID 178432317, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:9](OC(=O)C)(=O)[CH3:10]>>[CH3:9][C:10]1[NH:8][C:7]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=2[N:1]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
A mixture of 3,4-diaminopyridine (20.0 g, 183 mmol) and acetic anhydride (360 ml) was heated at 100° C. for 16 hours. The excess reagent was removed under reduced pressure, and the residue was purified by flash chromatography eluting with ethyl acetate:methanol, 3:1. The product was a brown solid, (15.5 g, 64%).
Aufarbeitung
- customThe excess reagent was removed under reduced pressure
- customthe residue was purified by flash chromatography
- washeluting with ethyl acetate
Quellen und Nachweise
- ORD-Eintrag
- ord-674bb7e6e50a4880a305861e8fa2b550
- Quelldatensatz
- uspto-grants-1992_06
- Patentnummer
- US05120747
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