1,2,3,4-Tetrahydro-1-methylquinoline → 1,2,3,4-Tetrahydroquinoline

HRID 893061

Reaktionsgleichung

Reaktionsgleichung von HRID 893061
Cl.C[N:3]1[C:12]2[C:7](=[CH:8][C:9](N=O)=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1.CN1C2C(=CC=CC=2)CCC1>>[NH:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1

Komponenten

3

Edukt 2

HCID 681091,2,3,4-Tetrahydro-1-methylquinolineHCID 190990131-Methyl-6-nitroso-1,2,3.4-tetrahydroquinoline hydrochloride

Produkt 1

HCID 694601,2,3,4-Tetrahydroquinoline

Versuchsvorschrift

1-methyl-6-nitroso-1,2,3.4-tetrahydroquinoline hydrochloride ##STR25## The title compound is prepared from 1-methyl1,2,3,4-tetrahydroquinoline (obtained from 1,2,3,4tetrahydroquinoline by heating with trimethylphosphate (according to Huisgen et al., Chem. Ber. 92, 203 (1959)). The crude product is produced in the usual manner analogous to Examples 10 and 11 and purified on silica gel 60 (Merck) with isopropanol/n-butylacetate/water=5:3:2. The title compound is obtained by dissolving this in acetone after addition of ethereal hydrochloric acid, m.p. 123°-124° C. (decomp.), TLC: silica gel 60, mobile phase: isopropanol/n-butylacetate/water=5:3:2, Rf =0.7.

Quellen und Nachweise

ORD-Eintrag
ord-dae7ceedec2d48afba15df48ed72fbf0
Quelldatensatz
uspto-grants-1992_06
Patentnummer
US05122244

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