Hydrochloric Acid → HCID 15728797, Verbindung

HRID 893262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 893262
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9]3=[C:10]([C:12](=[O:15])C(=O)[N:8]3[CH:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:6][CH2:5]2)[CH:11]=1.[OH-:22].[Na+].OO.Cl>O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([OH:22])=[O:15])[CH:11]=1)[NH:8][CH:7]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:6][CH2:5]2

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 19892016HCID 19892016, Verbindung

Produkt 1

HCID 15728797HCID 15728797, VerbindungAusbeute 96,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 8-chloro-5,6-dihydro-4-phenyl-4H-pyrrolo-[3,2,1-ij]quinoline-1,2-dione (3.4 g) and sodium hydroxide (2 g) in water (100 ml) was added 35% aqueous hydrogen peroxide solution (5 ml) and stirred at room temperature for an hour. The reaction mixture was acidified slightly by adding concentrated hydrochloric acid, the resulting precipitate was collected by filtration, washed and dried to give the title compound (3.17 g, 96.7%) as yellow crystals. This crystals was recrystallized from ethanol to pale yellow needles, mp 199°-200 ° C.

Aufarbeitung

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7101be7001e7461697560143b706ac13
Quelldatensatz
uspto-grants-1992_06
Patentnummer
US05124325

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