Lithium Hydroxide → HCID 15341834, Verbindung

HRID 893474Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 893474
[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([O:20]CC)=[O:19])=[C:6]([CH2:31][CH:32]=[CH2:33])[C:5]=1[O:34][CH3:35])=[O:3].[OH-].[Li+]>CO>[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([OH:20])=[O:19])=[C:6]([CH2:31][CH:32]=[CH2:33])[C:5]=1[O:34][CH3:35])=[O:3]

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 15341833HCID 15341833, Verbindung

Produkt 1

HCID 15341834HCID 15341834, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The compound of Example 55 (100 mg, 0.195 mmol) and 390 μl of 1 M lithium hydroxide (0.3896 mmol) were added to 2.0 ml of methanol, and the reaction mixture was stirred at room temperature for 4 hours. The solvent was removed under vacuum, 5.0 ml of water was added to the residue, and the mixture was acidified with 10% hydrochloric acid. The mixture was filtered, and the white solid which was recovered was dried in a 40° C. oven overnight to give the product.

Aufarbeitung

  1. customThe solvent was removed under vacuum, 5.0 ml of water
  2. additionwas added to the residue
  3. filtrationThe mixture was filtered
  4. customthe white solid which was recovered
  5. customwas dried in a 40° C. oven overnight
  6. customto give the product

Quellen und Nachweise

ORD-Eintrag
ord-d903b85a75c84494a26076e615d488ce
Quelldatensatz
uspto-grants-1992_06
Patentnummer
US05124350

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