Hydrochloric Acid → HCID 19890741, Verbindung

HRID 893684

Reaktionsgleichung

Reaktionsgleichung von HRID 893684
[Cl:1][CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[C:11]([CH3:15])=[CH:12][CH:13]=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].CO.Cl.[H][H]>[Pd].CC(O)C>[ClH:1].[Cl:1][CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[CH:11]([CH3:15])[CH2:12][CH2:13][CH2:14][C:7]2=[N:6][C:5]=1[CH3:16]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 46254083-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-oneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 19890741HCID 19890741, VerbindungAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A mixture of 9.5 parts of 3-(2-chloroethyl)-2,6-dimethyl-4H-pyrido[1,2-a]-pyrimidin-4-one, 160 parts of methanol and 40 parts of 2-propanol saturated with hydrogen chloride was hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over Hyflo and the filtrate was evaporated, yielding 9.5 parts (86%) of 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride (intermediate 175).

Aufarbeitung

  1. filtrationthe catalyst was filtered off over Hyflo
  2. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-49c11540862f43d087ab050cb26e22f8
Quelldatensatz
uspto-grants-1992_06
Patentnummer
US05126339

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