Water → 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid

HRID 894077Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 894077
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:13]([O:15]CCO)=[O:14])[NH:11][CH:12]=2)=[CH:4][CH:3]=1.[OH-].[K+].O>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:13]([OH:15])=[O:14])[NH:11][CH:12]=2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 130642732-Hydroxyethyl 4-(4-chlorophenyl)pyrrole-2-carboxylate

Produkt 1

HCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Crude 2-hydroxyethyl 4-(4-chlorophenyl)pyrrole-2-carboxylate (3 g.) was heated on a steam bath with potassium hydroxide (2 g.) in 25 ml. of water and 25 ml. of ethanol for 30 minutes. The balance of the ethanol was evaporated in vacuo, chloroform (25 ml.) was added and 4-(4-chlorophenyl)pyrrole-2-carboxylic acid (723 mg., m.p. 219°-222° C., ir(KBr): 3390, 3077 and 1695 cm.-1, m/e 221/223) recovered by filtration.

Aufarbeitung

  1. customThe balance of the ethanol was evaporated in vacuo, chloroform (25 ml.)
  2. additionwas added
  3. filtration4-(4-chlorophenyl)pyrrole-2-carboxylic acid (723 mg., m.p. 219°-222° C., ir(KBr): 3390, 3077 and 1695 cm.-1, m/e 221/223) recovered by filtration

Quellen und Nachweise

ORD-Eintrag
ord-beaab3b99dd7419685679af0097098d1
Quelldatensatz
uspto-grants-1981_08
Patentnummer
US04282242

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