Piperidine → Fenpropidin

HRID 894379Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 894379
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH3:15])[CH2:13]O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>[Pd].CO>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH3:15])[CH2:13][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 8082PiperidineHCID 92013Benzenepropanol, 4-(1,1-dimethylethyl)-beta-methyl-

Produkt 1

HCID 91694FenpropidinAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 153 parts of 3-p-tertiary butylphenyl-2-methyl-propanol, 70 parts of piperidine, 230 parts of methanol and 20 parts of catalyst, comprising 0.5% by weight of Pd and 5% by weight of Nd2O3 on Al2O3, is hydrogenated in a stirred autoclave of 1,000 parts by volume capacity, at 70° C. under a hydrogen pressure of 50 bar, until the pressure remains constant. The autoclave is then allowed to cool, the catalyst is filtered off and the filtrate is purified by distillation. 195 parts of N-(3'-(p-tertiary butylphenyl)-2'-methylpropyl)-piperidine, boiling point 117° C./0.2 mm Hg, are obtained. The yield is 94% of theory.

Aufarbeitung

  1. customis hydrogenated in a stirred autoclave of 1,000 parts by volume capacity, at 70° C. under a hydrogen
  2. temperatureto cool
  3. filtrationthe catalyst is filtered off
  4. distillationthe filtrate is purified by distillation

Quellen und Nachweise

ORD-Eintrag
ord-6cac709ee57a40e2a5318f5e20149460
Quelldatensatz
uspto-grants-1981_08
Patentnummer
US04283534

Notizen zur Reaktion

Wird geladen…