Reaktionsgleichung
NC1C=C(C(F)(F)F)C=C(F)[C:3]=1[OH:13].[N+:14]([C:17]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:18]=1Cl)([O-:16])=[O:15].C[O-].[Na+]>>[N+:14]([C:17]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:18]=1[O:13][CH3:3])([O-:16])=[O:15]Komponenten
Versuchsvorschrift
The 2-amino-4-trifluoromethylphenols (XI) required for the reaction sequence just described may be prepared by conventional methods. Thus, 2-amino-6-fluoro-4-trifluoromethylphenol may be prepared from 2-nitro-4-trifluoromethylchlorobenzene by reacting the latter with sodium methoxide to give 2-nitro-4-trifluoromethylanisole, and reducing this compound to 2-amino-4-trifluoromethylanisole. The latter compound may be diazotised and converted to its fluoborate salt and heated to give 2-fluoro-4-trifluoromethylanisole. This may then be nitrated to form 2-fluoro-6-nitro-4-trifluoromethylanisole, which is then reduced to give 2-amino-6-fluoro-4-trifluoromethylanisole. Finally the latter compound is heated with a demethylating agent, for example an excess of pyridine hydrochloride to give 2-amino-6-fluoro-4-trifluoromethylphenol.
Aufarbeitung
- customjust described may be prepared by conventional methods
Quellen und Nachweise
- ORD-Eintrag
- ord-f2a9138a863c4f1d8d80ba02c64ff258
- Quelldatensatz
- uspto-grants-1981_08
- Patentnummer
- US04285723
Verknüpfte Notizen
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