Morpholine → 4-(2,6-Difluoro-4-nitrophenyl)morpholine

HRID 895122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 895122
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1F>C(#N)C>[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1[N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 27827931,2,3-Trifluoro-5-nitrobenzene

Produkt 1

HCID 223856304-(2,6-Difluoro-4-nitrophenyl)morpholineAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Morpholine (1.2 g, 14.12 mmol) was added to a stirring solution of 3,4,5-trifluoronitro benzene (1 g, 5.65 mmol) in acetonitrile (15 mL) and the reaction mixture was refluxed for 5 h. A viscous liquid was obtained upon concentration, which was then poured into crushed ice. The solid thus obtained was filtered off and dried under reduced pressure to obtain the title compound (1.2 g, 88%).

Aufarbeitung

  1. temperaturethe reaction mixture was refluxed for 5 h
  2. customA viscous liquid was obtained upon concentration, which
  3. additionwas then poured
  4. custominto crushed ice
  5. customThe solid thus obtained
  6. filtrationwas filtered off
  7. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-548753ebd41d4ba1b662c37df832ddeb
Quelldatensatz
uspto-grants-2005_07
Patentnummer
US06914058B2

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