Trifluoromethanesulfonic anhydride → Trifluoro-methanesulfonic acid 2-fluoro-4-methoxy-phenyl ester 2-Fluoro-4-methoxy-phenol

HRID 895210

Reaktionsgleichung

Reaktionsgleichung von HRID 895210
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[OH:10].FC(F)(F)S([O:16][S:17]([C:20]([F:23])([F:22])[F:21])(=[O:19])=[O:18])(=O)=O>>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[OH:10].[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[O:16][S:17]([C:20]([F:21])([F:22])[F:23])(=[O:18])=[O:19]

Komponenten

3

Edukt 2

HCID 67749Trifluoromethanesulfonic anhydrideHCID 27745572-Fluoro-4-methoxyphenol

Produkt 1

HCID 86589678Trifluoro-methanesulfonic acid 2-fluoro-4-methoxy-phenyl ester 2-Fluoro-4-methoxy-phenol

Versuchsvorschrift

The title compound was prepared by reacting 2-fluoro-4-methoxy-phenol (2.8 g, 19.7 mmol) with trifluoromethanesulfonic anhydride (4.31 mL, 7.23 g, 25.6 mmol) according to method B to yield 3.86 g (68%) of a clear yellow oil. 1H NMR (DMSO-d6): δ 3.82 (3H, s), 6.89-6.94 (1H, m), 7.24 (1H, dd, J=12.49 Hz, J=2.98 Hz), 7.61 (1H, t, J=9.09 Hz).

Quellen und Nachweise

ORD-Eintrag
ord-e03a67a11c994c4f8fa579ac4d710fc9
Quelldatensatz
uspto-grants-2005_07
Patentnummer
US06914074B2

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