Sodium borohydride → (1-benzyl-4-chloro-2-(4-nitrophenyl)-1H-imidazol-5-yl)methanol

HRID 896945Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 896945
[BH4-].[Na+].[CH2:3]([N:10]1[C:14]([CH:15]=[O:16])=[C:13]([Cl:17])[N:12]=[C:11]1[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[CH2:3]([N:10]1[C:14]([CH2:15][OH:16])=[C:13]([Cl:17])[N:12]=[C:11]1[C:18]1[CH:19]=[CH:20][C:21]([N+:24]([O-:26])=[O:25])=[CH:22][CH:23]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydride2×HCID 150885051-benzyl-4-chloro-2-(4-nitrophenyl)-1H-imidazole-5-carbaldehyde

Produkt 1

HCID 15088539(1-benzyl-4-chloro-2-(4-nitrophenyl)-1H-imidazol-5-yl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Sodium borohydride (1.1 g, 29 mmole) was added in three portions to a stirred mixture of crude 1-benzyl-4-chloro-5-formyl-2-(4-nitrophenyl)imidazole (54.2 g, 88 mmole) in methanol (250 ml) at room temperature. After two hours, more sodium borohydride (0.51 g, 15 mmol) was added, the mixture was stirred for 30 minutes and the methanol was evaporated. The residue was mixed with water (250 ml) and extracted with methylene chloride (200 ml, 3×50 ml). The combined organic solutions were washed with water (2×50 ml) and dried (NaSO4) overnight.

Aufarbeitung

  1. customthe methanol was evaporated
  2. additionThe residue was mixed with water (250 ml)
  3. extractionextracted with methylene chloride (200 ml, 3×50 ml)
  4. washThe combined organic solutions were washed with water (2×50 ml)
  5. dry with materialdried (NaSO4) overnight

Quellen und Nachweise

ORD-Eintrag
ord-e686edc2b26845369706b226ea9640f9
Quelldatensatz
uspto-grants-2005_07
Patentnummer
US06921525B2

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