Hydrochloric Acid → 1-Bromo-4-(1-ethoxyethoxy)benzene

HRID 896952Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 896952
[C:1]([O:4][CH2:5][CH3:6])(=[O:3])[CH3:2].[CH:7]1[C:12](O)=[CH:11][CH:10]=[C:9]([Br:14])[CH:8]=1.Cl.C(OC=C)C>CCOCC>[CH2:5]([O:4][CH:1]([O:3][C:12]1[CH:11]=[CH:10][C:9]([Br:14])=[CH:8][CH:7]=1)[CH3:2])[CH3:6]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 78084-BromophenolHCID 8023Ethyl vinyl etherHCID 8857Ethyl Acetate

Produkt 1

HCID 27237611-Bromo-4-(1-ethoxyethoxy)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Into 100 ml of dehydrated ethyl acetate, were fed 11.0 g (50 mmol) of p-bromophenol, and 4.8 ml of a solution composed of hydrochloric acid (1.0 mol/L) and ether, and the mixture was set at 40° C. Into the mixture, 10.8 g (150 mmol) of ethylvinylether was added dropwise, and the mixture was kept with stirring for one night. After completion of the reaction, the reaction solution was rinsed with sodium hydrogen carbonate solution and then rinsed with water to remove solvent. By purifying with silica gel column chromatography (eluate: hexane), 10.7 g (36.5 mmol) of 1-(1-ethoxy)ethoxy-4-bromobenzene was obtained.

Aufarbeitung

  1. customwas set at 40° C
  2. customAfter completion of the reaction
  3. washthe reaction solution was rinsed with sodium hydrogen carbonate solution
  4. washrinsed with water
  5. customto remove solvent
  6. customBy purifying with silica gel column chromatography (eluate: hexane)

Quellen und Nachweise

ORD-Eintrag
ord-ffd1f9421537494f826ee392e6c85942
Quelldatensatz
uspto-grants-2005_07
Patentnummer
US06921623B2

Notizen zur Reaktion

Wird geladen…