Phenylacetaldehyde → 2-Phenyl-1-(thiophene-2-sulfonylamino)-ethyl-phosphonic Acid Diethyl Ester

HRID 896986Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 896986
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH2:9])(=[O:8])=[O:7].[P:10]([O-:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13].[C:18]1([CH2:24][CH:25]=O)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(Cl)(=O)C>[CH2:12]([O:11][P:10]([CH:25]([NH:9][S:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)(=[O:8])=[O:7])[CH2:24][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:17])[O:14][CH2:15][CH3:16])[CH3:13]

Komponenten

5

Edukt 3

HCID 998PhenylacetaldehydeHCID 728812-ThiophenesulfonamideHCID 3780918Diethylphosphite

Produkt 1

HCID 228909322-Phenyl-1-(thiophene-2-sulfonylamino)-ethyl-phosphonic Acid Diethyl EsterAusbeute 349,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6367Acetyl chlorideLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a suspension of sulfonamide (vi) (500 mg; 0.31 mmol) in acetyl chloride (5 mL) was slowly added diethyl phosphite (400 μL; 0.31 mmol). The reaction was cooled to 0° C. and then phenylacetaldehyde (450 μL; 0.39 mmol) was added dropwise. The reaction was gradually warmed to ambient temperature and after 6 hrs the homogeneous solution was concentrated. The residue was diluted with dichloromethane (25 mL) then washed successively with water (10 mL), saturated sodium bicarbonate (10 mL) and brine (10 mL). The combined organic extracts were dried (MgSO4), evaporated and initially purified by flash chromatography (ethyl acetate-hexanes; 3:2). A second purification by flash chromatography (acetone-hexanes; 3:7) yielded diethyl phosphonate (xii) (437 mg, 35%) as a colorless solid; 1H NMR (400 MHz, CDCl3) δH 1.22 (t, J=7 Hz, 3H, OCH2CH3), 1.26 (t, J=7 Hz, 3H, OCH2CH3), 2.89 (dt, J=8, 14 Hz, 1H, CHPh), 3.12 (dt, J=6, 14 Hz, 1H, CHPh), 3.96-4.23 (m, 5H, NCHP and OCH2CH3), 6.38 (dd, J=2, 9.5 Hz, 1H, NH), 6.92-6.93 (m, 1H, Ar—H), 7.12-7.20 (m, 5H, Ar—H), 7.33-7.34 (m, 1H, Ar—H), 7.43-7.45 (m, 1H, Ar—H).

Aufarbeitung

  1. temperatureThe reaction was gradually warmed to ambient temperature and after 6 hrs the homogeneous solution
  2. concentrationwas concentrated
  3. additionThe residue was diluted with dichloromethane (25 mL)
  4. washthen washed successively with water (10 mL), saturated sodium bicarbonate (10 mL) and brine (10 mL)
  5. dry with materialThe combined organic extracts were dried (MgSO4)
  6. customevaporated
  7. custominitially purified by flash chromatography (ethyl acetate-hexanes; 3:2)
  8. customA second purification by flash chromatography (acetone-hexanes; 3:7)

Quellen und Nachweise

ORD-Eintrag
ord-8a87623a2eee4e03aeb1dea61cf47f3e
Quelldatensatz
uspto-grants-2005_07
Patentnummer
US06921756B2

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