Water → Perindopril erbumine monohydrate

HRID 898741

Reaktionsgleichung

Reaktionsgleichung von HRID 898741
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]>CC(C)=O>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]

Komponenten

4

Edukt 2

HCID 962WaterHCID 441313Perindopril Erbumine

Produkt 1

HCID 9847044Perindopril erbumine monohydrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Perindopril erbumine (10 gms) was suspended in acetone (80 ml). To this was added water (0.4 ml) and the contents heated to dissolve the solids and cooled to ambient. The resulting slurry was filtered to obtain perindopril erbumine monohydrate (9.4 gms).

Aufarbeitung

  1. temperaturethe contents heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled
  4. filtrationThe resulting slurry was filtered

Quellen und Nachweise

ORD-Eintrag
ord-274ca6923c744e3db9f70350da48dd55
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07351840B2

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