Water → Perindopril erbumine monohydrate

HRID 898742

Reaktionsgleichung

Reaktionsgleichung von HRID 898742
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]>C(#N)C>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]

Komponenten

4

Edukt 2

HCID 962WaterHCID 441313Perindopril Erbumine

Produkt 1

HCID 9847044Perindopril erbumine monohydrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Perindopril erbumine (5 gms) was suspended in acetonitrile (75 ml). To this was added water (0.4 ml) and the contents heated to dissolve the solids and cooled to 0 EC. The resulting slurry was filtered to obtain perindopril erbumine monohydrate (2.9 gms).

Aufarbeitung

  1. temperaturethe contents heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled to 0 EC
  4. filtrationThe resulting slurry was filtered

Quellen und Nachweise

ORD-Eintrag
ord-5a42d62a17dd43a8b107ff4b4ae0b469
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07351840B2

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