244205-60-5 → 1-Amino-2-phenylcyclopropane-1-carboxylic acid

HRID 898860Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 898860
C(OC([NH:8][C@:9]1([C:18]([OH:20])=[O:19])[CH2:11][C@H:10]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O)(C)(C)C.Cl.O1CCOCC1>C(OCC)C>[NH2:8][C@@:9]1([C:18]([OH:20])=[O:19])[CH2:11][C@@H:10]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Komponenten

4

Edukt 2

HCID 2734148244205-60-5HCID 204431481,4-Dioxane hydrochloride

Produkt 1

HCID 1338301-Amino-2-phenylcyclopropane-1-carboxylic acidAusbeute 101,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To commercially available (1R,2S)-1-tert-butoxycarbonylamino-2-phenylcyclopropanecarboxylic acid (130 mg, 0.45 mmol) was added 4N hydrochloric acid—1,4-dioxane solution (2.0 mL, 16 v/w) and the mixture was stirred for 1 hr at room temperature. Diethyl ether (1.0 mL) was added thereto and the mixture was stirred for 5 min, after which the resulting crystals were collected by filtration. The crystals were washed with diethyl ether (1.0 mL) and dried under reduced pressure to give the title compound (81 mg, white powder, yield 84%).

Aufarbeitung

  1. stirringthe mixture was stirred for 5 min
  2. filtrationafter which the resulting crystals were collected by filtration
  3. washThe crystals were washed with diethyl ether (1.0 mL)
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-afd4e59a7c8a428b82db1d71553f88a6
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07351825B2

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