Hydrochloric Acid → (4,5-Dichloro-1H-imidazol-2-yl)methanol

HRID 900750Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 900750
[OH-:1].[K+].[Cl:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[Cl:9].[CH2:10]=O.Cl>O>[Cl:3][C:4]1[N:5]=[C:6]([CH2:10][OH:1])[NH:7][C:8]=1[Cl:9]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 14797Potassium HydroxideHCID 1400184,5-Dichloroimidazole

Produkt 1

HCID 17974733(4,5-Dichloro-1H-imidazol-2-yl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Potassium hydroxide (0.12 g, 2.14 mmol) in water (4 ml) was added to 4,5-dichloroimidazole, and the suspension was stirred for 35 min. Paraformaldehyde (0.11 g, 3.66 mmol) was added portionwise and the reaction mixture was stirred over night, then acidified with dilute HCl to pH 1 and then concentrated in vacuo to give a white solid, 0.6 g (98%).

Aufarbeitung

  1. stirringthe reaction mixture was stirred over night
  2. concentrationconcentrated in vacuo
  3. customto give a white solid, 0.6 g (98%)

Quellen und Nachweise

ORD-Eintrag
ord-bf606cbed2f74542bad9de68bf2a5821
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07361660B2

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