Methanol → 1H-Imidazole-5-propanoic acid

HRID 901115Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 901115
[CH:1]1[N:5]=[CH:4][NH:3][C:2]=1/[CH:6]=[CH:7]/[C:8]([OH:10])=[O:9].CO>Cl.[Pd]>[NH:3]1[C:2]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[CH:1][N:5]=[CH:4]1

Komponenten

5

Edukt 2

HCID 887MethanolHCID 736715Urocanic Acid2×

Produkt 1

HCID 706301H-Imidazole-5-propanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

Urocanic acid (compound i, where R2 is H)(1.38 g, 10.0 mmol) was dissolved in 5% aqueous HCl (20 ml) plus MeOH (15 ml) containing 10% Pd on carbon (100 mg) and the mixture was shaken overnight under about 30 psi H2. The catalyst was removed by filtration through a 3 cm pad of diatomaceous earth and the filtrate was concentrated to a solid and dried overnight under vacuum. The crude material was used without further purification. Mass spec. 141.4 MH+

Aufarbeitung

  1. customThe catalyst was removed by filtration through a 3 cm pad of diatomaceous earth
  2. concentrationthe filtrate was concentrated to a solid
  3. customdried overnight under vacuum
  4. customThe crude material was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-5fec21e9b37c42c29601326e0a4b3374
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07361656B2

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