4-(4-Methoxynaphthalen-1-yloxy)-1-nitrobenzene → 4-(4-Methoxy-naphthalen-1-yloxy)aniline

HRID 901705Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 901705
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)=[CH:5][CH:4]=1>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][C:14]2[CH:15]=[CH:16][C:17]([NH2:20])=[CH:18][CH:19]=2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 1

HCID 669773744-(4-Methoxynaphthalen-1-yloxy)-1-nitrobenzene

Produkt 1

HCID 669774504-(4-Methoxy-naphthalen-1-yloxy)aniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The nitro intermediate (10 mmol) obtained above was dissolved in EtOAc (50 mL) and hydrogenated in the presence of 10% Pd/C (360 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(4-methoxy-naphthalen-1-yloxy)aniline, which was used directly for further transformation without further purification.

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered
  2. customto remove the catalyst
  3. customThe solvent was removed in vacuuo

Quellen und Nachweise

ORD-Eintrag
ord-6dcf70048e834e8a9d2214ebe917e1f0
Quelldatensatz
uspto-grants-2008_04
Patentnummer
US07361678B2

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