Methyl 2-[(2-nitrophenyl)amino]acetate → 2(1H)-Quinoxalinone, 3,4-dihydro-
Reaktionsgleichung
C[O:2][C:3](=O)[CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N+:12]([O-])=O>C(OCC)(=O)C.CO.[Pd]>[NH:12]1[C:7]2[C:6](=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:5][CH2:4][C:3]1=[O:2]Komponenten
5
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
A solution of N-(2-nitrophenyl)glycine methyl ester (740 mg, 3.6 mmol) in ethyl acetate (50 ml) and methanol (25 ml) was hydrogenated at atmospheric pressure over a catalytic amount of 10% palladium on carbon. After 1 h the mixture was filtered and reduced to afford 1,2,3,4-tetrahydroquinoxalin-2-one as a yellow solid (530 mg, 99%).
Aufarbeitung
- filtrationAfter 1 h the mixture was filtered
Quellen und Nachweise
- ORD-Eintrag
- ord-b71da26728394ec1875e6794cb8bd16c
- Quelldatensatz
- uspto-grants-2008_04
- Patentnummer
- US07365065B2
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