Sulfuric Acid → N-tert-Butyl-3,3-dimethyl-2-oxobutanamide

HRID 903492

Reaktionsgleichung

Reaktionsgleichung von HRID 903492
[C:1]([C:7]#[N:8])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].S(=O)(=O)(O)[OH:10].[CH3:14][C:15](=[CH2:17])[CH3:16]>C(O)(=O)C>[C:15]([NH:8][C:7](=[O:10])[C:1]([C:2]([CH3:5])([CH3:4])[CH3:3])=[O:6])([CH3:16])([CH3:14])[CH3:17]

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 8255IsobutyleneHCID 945273,3-Dimethyl-2-oxobutanenitrile

Produkt 1

HCID 13355144N-tert-Butyl-3,3-dimethyl-2-oxobutanamideAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

There were present in a stirrer apparatus protected against moisture 111 grams (1.0 mole) of pivaloyl cyanide, 150 grams (1.5 moles) of concentrated sulfuric acid and 150 ml of glacial acetic acid and there were led in during one hour under stirring at 0°-5° C. 112 grams (2.0 moles) of isobutylene. Then the mixture was warmed up to room temperature and stirred further for 4 hours. Then the mixture was poured on 500 grams of ice and after thorough stirring the precipitated amide was filtered off with suction. After the drying in the vacuum drying cabinet, there were isolated 161 grams of analytically pure trimethyl pyruvic acid-N-t-butylamide which corresponds to a yield of 87% based on the acyl cyanide employed. The amide has a melting point of 65° C.

Aufarbeitung

  1. customThere were present in a stirrer
  2. customwere led in during one hour
  3. stirringstirred further for 4 hours
  4. filtrationwas filtered off with suction
  5. customAfter the drying in the vacuum drying cabinet

Quellen und Nachweise

ORD-Eintrag
ord-526759c3730048e3a8ddb69b99076198
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04228082

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