Reaktionsgleichung
[C:1]([O:10][CH3:11])(=[O:9])[CH2:2][CH2:3][CH2:4][C:5]([O:7]C)=O.[CH3:12][NH:13][CH2:14][CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[NH:18][CH:17]=1.Cl>>[CH3:12][N:13]([C:5](=[O:7])[CH2:4][CH2:3][CH2:2][C:1]([O:10][CH3:11])=[O:9])[CH2:14][CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[NH:18][CH:17]=1Komponenten
Reaktionsbedingungen
- Temperatur
- 150 °C
Versuchsvorschrift
8.0 g of dimethyl glutarate were added to 8.70 g of N-methyl-tryptamine (i.e., 3-(2-methylaminoethyl)-indole), and the mixture was heated at 150° C. under reduced pressure for 2 hours. After the reaction was completed, the mixture was acidified with dilute hydrochloric acid and then extracted with ethyl acetate. The extract was washed with water, an aqueous saturated sodium bicarbonate solution and an aqueous saturated sodium chloride solution, successively. The washed extract was dried and evaporated under reduced pressure to remove solvent. The residue thus obtained was recrystallized from a mixture of ethyl acetate and n-hexane. 11.3 g of N-methyl-N-(4-methoxycarbonylbutyryl)-tryptamine (i.e., 3-[2-(N-methyl-4-methoxycarbonylbutanamido)ethyl]-indole) were thereby obtained. M.p. 101°-102° C. Yield: 70%
Aufarbeitung
- extractionextracted with ethyl acetate
- washThe extract was washed with water
- extractionThe washed extract
- customwas dried
- customevaporated under reduced pressure
- customto remove solvent
- customThe residue thus obtained
- customwas recrystallized from a mixture of ethyl acetate and n-hexane
Quellen und Nachweise
- ORD-Eintrag
- ord-6716595877b943c0bcbc809cc2a611a5
- Quelldatensatz
- uspto-grants-1980_10
- Patentnummer
- US04228168
Verknüpfte Notizen
Wird geladen…