Water → 4-(3'-Azidopropyl)-piperidine

HRID 903863

Reaktionsgleichung

Reaktionsgleichung von HRID 903863
[N-:1]=[N+:2]=[N-:3].[Na+].Br.Br[CH2:7][CH2:8][CH2:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.O>CO>[N:1]([CH2:7][CH2:8][CH2:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[N+:2]=[N-:3]

Komponenten

5

Edukt 3

HCID 962WaterHCID 33557Sodium AzideHCID 135032154-(3-Bromopropyl)piperidine hydrobromide

Produkt 1

HCID 135032204-(3'-Azidopropyl)-piperidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Sodium azide (1 g) was added to a mixture of 4-(3'-bromopropyl)-piperidine hydrobromide (2 g), water (7 ml) and methanol (7 ml). The pH of the mixture was adjusted to 6.3, and the resulting solution was refluxed for 2 hours. After cooling, methanol was evaporated, 30 percent aqueous sodium hydroxide was added and the mixture was extracted several times with ether. The ether extracts were dried and evaporated to leave the desired compound as an oil. The IR-spectrum (CHCl3) showed strong bands at 2925, 2100 and 1450 cm-1.

Aufarbeitung

  1. temperaturethe resulting solution was refluxed for 2 hours
  2. temperatureAfter cooling
  3. custommethanol was evaporated
  4. addition30 percent aqueous sodium hydroxide was added
  5. extractionthe mixture was extracted several times with ether
  6. dry with materialThe ether extracts were dried
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-806b04d0240c4ed3bee89453fef8cddb
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04229443

Verknüpfte Notizen

Wird geladen…