Water → HCID 21782073, Verbindung

HRID 903888

Reaktionsgleichung

Reaktionsgleichung von HRID 903888
[CH2:1]([C:3]1([C:8]([OH:10])=[O:9])[NH:7][CH2:6][CH2:5][S:4]1)[CH3:2].O.[C:12](=O)(O)[O-].[Na+]>Cl.CO>[CH3:12][O:9][C:8]([C:3]1([CH2:1][CH3:2])[NH:7][CH2:6][CH2:5][S:4]1)=[O:10]

Komponenten

5

Edukt 3

HCID 962WaterHCID 198462Thiazolidinecarboxylic acid, 2-ethyl-HCID 516892Sodium Bicarbonate

Produkt 1

HCID 21782073HCID 21782073, VerbindungAusbeute 18,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21893726Hydrochloride methanolLösungsmittel

Versuchsvorschrift

10.0 g of the 2-ethyl-thiazolidine-2-carboxylic acid thus obtained was dissolved in 200 ml of 20% hydrogen chloride-methanol solution. After being refluxed for 30 minutes, the reaction mixture was concentrated under reduced pressure to afford a residue, to which was added water, and was then neutralized with an aqueous saturated solution of sodium bicarbonate. Upon extracting with ethyl acetate, the extract was chromatographed on a column of silica gel to give 2.0 g (yield 18.4%) of 2-ethyl-thiazolidine-2-carboxylic acid methyl ester with a reflex index of nD26 1.501.

Aufarbeitung

  1. temperatureAfter being refluxed for 30 minutes
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customto afford a residue
  4. extractionUpon extracting with ethyl acetate
  5. customthe extract was chromatographed on a column of silica gel

Quellen und Nachweise

ORD-Eintrag
ord-49855af150524eecbe110a1c074cd2b8
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04229461

Verknüpfte Notizen

Wird geladen…