p-Toluenesulfonic acid → 2-Tetrahydropyranyl 4-(8-cyclohexyloctylamino)benzoate

HRID 905274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 905274
[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:24]=[CH:23][C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:25]1[CH:30]=[CH:29][CH2:28][CH2:27][CH2:26]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:24]=[CH:23][C:19]([C:20]([O:22][CH:26]3[CH2:27][CH2:28][CH2:29][CH2:30][O:25]3)=[O:21])=[CH:18][CH:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 6101p-Toluenesulfonic acidHCID 80803,4-dihydro-2H-pyranHCID 204757724-(8-Cyclohexyloctylamino)benzoic acid

Produkt 1

HCID 204758342-Tetrahydropyranyl 4-(8-cyclohexyloctylamino)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 7 g. 4-(8-cyclohexyloctylamino)benzoic acid, 2 g. 2,3-dihydropyran and 100 mg. anhydrous p-toluenesulfonic acid in 50 ml. toluene is stirred at room temperature for 20 hours. The solution is washed with saturated sodium bicarbonate, dried, and condensed. The residue is crystallized from methylcyclohexane to white crystals.

Aufarbeitung

  1. additionA mixture of 7 g
  2. washThe solution is washed with saturated sodium bicarbonate
  3. customdried
  4. customcondensed
  5. customThe residue is crystallized from methylcyclohexane to white crystals

Quellen und Nachweise

ORD-Eintrag
ord-82e37ac1a3fc4c2c9dac6c33089a34dd
Quelldatensatz
uspto-grants-1983_12
Patentnummer
US04423051

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