Perchloric Acid → 4-Hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

HRID 905898Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 905898
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]([CH3:13])[C:4](=[O:14])[C:3]=1[C:15]([O:17]C(C)(C)C)=[O:16].Cl(O)(=O)(=O)=O>C(#N)C>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([I:12])[CH:10]=2)[N:5]([CH3:13])[C:4](=[O:14])[C:3]=1[C:15]([OH:17])=[O:16]

Komponenten

4

Edukt 2

HCID 24247Perchloric AcidHCID 59340042tert-Butyl 4-hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

Produkt 1

HCID 593400774-Hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 4-hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (4.1 g, 10 mmol) and Acetonitrile (20 ml), cooled in an ice bath, was added 70% perchloric acid (0.2 ml) and the mixture was stirred 30 sec. A yellow solid was filtered. Yield=0.5 g.

Aufarbeitung

  1. filtrationA yellow solid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-54d74348b6344e82847dfc1aa782a28d
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08012968B2

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