Water → 4-Bromo-1-(bromomethyl)-2-chlorobenzene

HRID 906492

Reaktionsgleichung

Reaktionsgleichung von HRID 906492
[Cl:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[CH3:9].C1C(=O)N([Br:17])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C.O>C(Cl)(Cl)(Cl)Cl>[Br:8][C:6]1[CH:5]=[CH:4][C:3]([CH2:9][Br:17])=[C:2]([Cl:1])[CH:7]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 27355544-Bromo-2-chlorotoluene

Produkt 1

HCID 219144864-Bromo-1-(bromomethyl)-2-chlorobenzeneAusbeute 55,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

5.0 g of 2-chloro-4-bromotoluene are dissolved in 120 ml of CCl4. 4.3 g of NBS and 1.6 g of AIBN are added. The mixture is heated at reflux for 15 hours, water is added, the two phases are separated and then extraction is carried out with CH2Cl2. Purification is carried out by chromatography on a silica column eluted with petroleum ether. 3.8 g of liquid are obtained.

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 15 hours
  3. customthe two phases are separated
  4. extractionextraction
  5. customPurification
  6. washeluted with petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-1d17187996294ba3befa45d30c8cc81c
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08012991B2

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