Dimethylamine → Dimethyl-[(1-methyl-1H-indol-3-yl)-o-tolyl-methyl]-amine

HRID 9068

Reaktionsgleichung

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[Cl-].[CH3:12][C:13]1[CH:22]=[CH:21][CH:20]=[CH:19][C:14]=1[CH:15]=[N+:16]([CH3:18])[CH3:17].CC1C=CC=CC=1C=O.CNC>>[CH3:17][N:16]([CH3:18])[CH:15]([C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:2]([CH3:1])[CH:3]=1)[C:14]1[CH:19]=[CH:20][CH:21]=[CH:22][C:13]=1[CH3:12]

Komponenten

Edukt 4

HCID 674Dimethylamine

HCID 107222-Methylbenzaldehyde

HCID 117811-Methylindole

HCID 21985341(2-Methyl-benzylidene)-dimethylammonium chloride

Produkt 1

HCID 21985352Dimethyl-[(1-methyl-1H-indol-3-yl)-o-tolyl-methyl]-amine

Versuchsvorschrift

The preparation was carried out in accordance with general synthesis instructions 4 from 1-methyl-1H-indole and (2-methyl-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 2-methyl-benzaldehyde and dimethylamine.

Quellen und Nachweise

ORD-Eintrag: ord-9f30dee72cee4b8e950846dc191f7f87
Quelldatensatz: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07091220B2

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