benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate → (2S,3S)-2-isopropyl-3-methylpyrrolidin-3-ol

HRID 906961Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 906961
[OH:1][C@@:2]1([CH3:20])[CH2:6][CH2:5][N:4](C(OCC2C=CC=CC=2)=O)[C@H:3]1[CH:17]([CH3:19])[CH3:18]>O>[CH:17]([C@H:3]1[C@@:2]([CH3:20])([OH:1])[CH2:6][CH2:5][NH:4]1)([CH3:19])[CH3:18]

Komponenten

3

Edukt 1

HCID 59273084benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate

Produkt 1

HCID 59273040(2S,3S)-2-isopropyl-3-methylpyrrolidin-3-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate (1.78 g) and 50% water containing −10% Pd/C (0.09 g), the title compound was obtained as a colorless solid (yield: 1.07 g, yield: 89%).

Quellen und Nachweise

ORD-Eintrag
ord-ef38d6cc78fc4ae899931dfecc2f47c7
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08013008B2

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