(1,4-Dibenzyl-1,4-diazepan-5-yl)methanol → HCID 23090220, Verbindung
Reaktionsgleichung
C([N:8]1[CH2:14][CH2:13][CH:12]([CH2:15][OH:16])[N:11](CC2C=CC=CC=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[NH:8]1[CH2:14][CH2:13][CH:12]([CH2:15][OH:16])[NH:11][CH2:10][CH2:9]1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of (1,4-dibenzyl-1,4-diazepan-5-yl)methanol (500 mg) (prepared as described in Chin. Chem. Lett., 2001, 12, 951) in methanol (10 mL) was added 5% wt. palladium on charcoal (171 mg) and the mixture stirred under a 5 bar hydrogen atmosphere for 16 hours. The reaction mixture was filtered through celite and the liquors concentrated to dryness to give the sub-title compound (210 mg) as a colourless oil.
Aufarbeitung
- filtrationThe reaction mixture was filtered through celite
- concentrationthe liquors concentrated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-f41b54ce16414a538199451ef273fd1c
- Quelldatensatz
- uspto-grants-2011_09
- Patentnummer
- US08012979B2
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