Chlorotrimethylsilane → 2-[4-dimethylamino-4-(3-fluorophenyl)cyclohexylidene]-N-(3-phenylpropyl)acetamide Hydrochloride
Reaktionsgleichung
[CH3:1][N:2]([CH3:29])[C:3]1([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:11])[CH2:5][CH2:4]1.C[Si](C)(C)[Cl:32]>CC(CC)=O>[ClH:32].[CH3:29][N:2]([CH3:1])[C:3]1([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[CH:23]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:11])[CH2:5][CH2:4]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2-[4-Dimethylamino-4-(3-fluorophenyl)cyclohexylidene]-N-(3-phenylpropyl)acetamide (150 mg, 0.35 mmol) was dissolved in ethyl methyl ketone (10 ml) with gentle heating and trimethylchlorosilane (0.082 ml, 0.65 mmol) was added. After stirring at RT for 2 h, the reaction mixture was concentrated to dryness. The residue was stirred briefly with ether (10 ml) and the hydrochloride was isolated as a colourless solid with an m.p. of 230-233° C. in a yield of 98% (184 mg).