Water → HCID 22316930, Verbindung

HRID 910220

Reaktionsgleichung

Reaktionsgleichung von HRID 910220
[C:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C1(C)C=CC(S([CH2:21][N:22]=C=O)(=O)=O)=CC=1.[C:26](=O)([O-])[O-].[K+].[K+].O>CO>[O:3]1[C:1]([C:4]2[CH:11]=[CH:10][C:7]([C:8](=[O:9])[CH3:26])=[CH:6][CH:5]=2)=[CH:2][N:22]=[CH:21]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 5009465Benzaldehyde, 4-acetyl-HCID 117890781-Isocyanatomethanesulfonyl-4-methylbenzene

Produkt 1

HCID 22316930HCID 22316930, VerbindungAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

4-Acetylbenzaldehyde (2.96 g) and p-toluenesulfonylmethylisocyanate (4.69 g) were dissolved in methanol (200 mL). Potassium carbonate (3.32 g) was added to the solution, and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The solvent was evaporated, and the residue was purified through silica gel column chromatography (dichloromethane:methanol=100:1), followed by concentration under reduced pressure, to thereby yield the title compound (3.14 g).

Aufarbeitung

  1. extractionfollowed by extraction with ethyl acetate
  2. customThe solvent was evaporated
  3. customthe residue was purified through silica gel column chromatography (dichloromethane:methanol=100:1)
  4. concentrationfollowed by concentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-237d81c8fa0d45dd944acb723a4abb9f
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022075B2

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