Acetone → 3-(4-Isopropyl-piperazin-1-yl)-phenol

HRID 910274

Reaktionsgleichung

Reaktionsgleichung von HRID 910274
[CH3:1][C:2]([CH3:4])=O.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].[N:19]1([C:25]2[CH:26]=[C:27]([OH:31])[CH:28]=[CH:29][CH:30]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.C(=O)(O)[O-].[Na+]>C1COCC1>[CH:2]([N:22]1[CH2:21][CH2:20][N:19]([C:25]2[CH:26]=[C:27]([OH:31])[CH:28]=[CH:29][CH:30]=2)[CH2:24][CH2:23]1)([CH3:4])[CH3:1]

Komponenten

6

Edukt 4

HCID 180AcetoneHCID 516892Sodium BicarbonateHCID 27365971-(3-Hydroxyphenyl)piperazineHCID 5049666Sodium triacetoxyborohydride

Produkt 1

HCID 584994803-(4-Isopropyl-piperazin-1-yl)-phenolAusbeute 59,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Acetone (1.95 g) and NaBH(OAc)3 (7.12 g) were added to a solution of 3-piperazin-1-yl-phenol (2.00 g) in THF (40 ml), and the mixture was stirred at room temperature for 18 hours. Saturated aqueous sodium bicarbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was dried (MgSO4) and filtered to give the titled compound (1.48 g, colorless powder).

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-f0cc949488174e2aa69b178879108f42
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022091B2

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