1-Methylpiperazine → 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

HRID 910681Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 910681
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>CCO>[Cl:1][C:2]1[N:7]=[C:6]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)[CH:5]=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 531671-MethylpiperazineHCID 775312,4-Dichloropyrimidine

Produkt 1

HCID 17142252-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 2,4-dichloropyrimidine (740 mg, 5 mmol) in EtOH (15 mL) was slowly added 1-methylpiperazine (550 mg, 5.5 mmol). The resulting mixture was stirred at room temperature overnight, then was concentrated, diluted with water, and extracted with CH2Cl2. The organic layer was dried and concentrated to yield 2-chloro-4-(4-methyl-piperazin-1-yl)-pyrimidine.

Aufarbeitung

  1. concentrationwas concentrated
  2. additiondiluted with water
  3. extractionextracted with CH2Cl2
  4. customThe organic layer was dried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-73e60837939b41ff82c9ae5a0b6276c6
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022209B2

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