1-Methylpiperazine → 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

HRID 910690Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 910690
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>C(O)C>[Cl:1][C:2]1[N:7]=[C:6]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)[CH:5]=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 531671-MethylpiperazineHCID 775312,4-Dichloropyrimidine

Produkt 1

HCID 17142252-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 2,4-dichloropyrimidine (447 mg, 3 mmol) in ethanol (10 mL) was added 1-methylpyperazine (360 mg, 3.6 mmol). The resulting mixture was stirred at room temperature overnight. The resulting white solid was collected by filtration and washed with ethanol, Na2CO3 solution and water and ethanol.

Aufarbeitung

  1. filtrationThe resulting white solid was collected by filtration
  2. washwashed with ethanol, Na2CO3 solution and water and ethanol

Quellen und Nachweise

ORD-Eintrag
ord-5aa3ce636099429b85a813584cc09145
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022209B2

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