Methyl chloroformate → Methyl (2-(hydroxymethyl)phenyl)carbamate

Reaktionsgleichung

N[CH:2]([OH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:10][O:11][C:12](Cl)=[O:13].CC[N:17](C(C)C)C(C)C>>[CH3:10][O:11][C:12](=[O:13])[NH:17][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][OH:9]

Komponenten

Edukt 3

HCID 6586Methyl chloroformate

HCID 81531Diisopropylethylamine

HCID 5250324HCID 5250324, Verbindung

Produkt 1

HCID 54236756Methyl (2-(hydroxymethyl)phenyl)carbamate

Versuchsvorschrift

Reaction of aminobenzylalcohol (3 g) with methylchloroformate (1.9 ml) in the presence of DIPEA (12.8 ml) was performed according to the method described in example 22. The residue was chromatographed on silica gel in dichloromethane/ethyl acetate=25/1 as eluent. Yield: 4.19 g.