Bromine → 2-Bromo-1-[2-(trifluoromethyl)phenyl]propan-1-one

HRID 912576Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 912576
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:12])[CH2:10][CH3:11].[Br:15]Br>C(Cl)(Cl)(Cl)Cl>[Br:15][CH:10]([CH3:11])[C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:13])([F:14])[F:1])=[O:12]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 1400402-(Trifluoromethyl)propiophenone

Produkt 1

HCID 201874742-Bromo-1-[2-(trifluoromethyl)phenyl]propan-1-oneAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel2×

Versuchsvorschrift

To a solution of 2′-trifluoromethyl-propiophenone (10 g, 48 mmol) in carbon tetrachloride (50 ml) was added a solution of bromine (2.72 mL, 52.8 mmol) in carbon tetrachloride (20 mL) dropwise. After the addition was complete, stirring was continued for another 2h. The solution was washed with satd NaHCO3 and water, dried (anhyd Na2SO4) and concentrated under reduced pressure to give 2-bromo-1-(2-trifluoromethyl-phenyl)-propan-1-one as an oil (12.8 g, 95%), which was used in the next step without purification. 1H-NMR (CDCl3): δ 7.73 (m, 2H), 7.58-7.67 (m, 2H), 4.96 (q, 1H), 1.90 (d, 3H). To a solution of 2′-trifluoromethyl-propiophenone (10 g, 48 mmol) in carbon tetrachloride (50 ml) was added a solution of bromine (2.72 mL, 52.8 mmol) in carbon tetrachloride (20 m

Aufarbeitung

  1. additionAfter the addition
  2. washThe solution was washed with satd NaHCO3 and water
  3. dry with materialdried (anhyd Na2SO4)
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ca203ea7a7064ec5a1bed8c060c78038
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026237B2

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