Methyl triflate → 5-Methoxy-4-azatricyclo[4.3.1.1,3,8]undec-4-ene

HRID 913050Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 913050
[CH:1]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:3]([NH:4][C:5]3=[O:12])[CH2:2]1)[CH2:9]2.O(C)S([C:17](F)(F)F)(=O)=O>C(Cl)Cl>[CH3:17][O:12][C:5]1[CH:6]2[CH2:11][CH:1]3[CH2:9][CH:8]([CH2:10][CH:3]([CH2:2]3)[N:4]=1)[CH2:7]2

Komponenten

4

Edukt 2

HCID 9526Methyl triflateHCID 2866474-Azatricyclo[4.3.1.13,8]undecan-5-one

Produkt 1

HCID 866090545-Methoxy-4-azatricyclo[4.3.1.1,3,8]undec-4-ene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-azatricyclo[4.3.1.13,8]undecan-5-one 3-A (1.00 g, 6.05 mmol) in 10 mL methylene chloride was added methyl triflate (2.98 g, 3 eq) and the reaction was heated at reflux for 20 min, after which time all volatiles were removed under reduced pressure to afford crude 5-methoxy-4-azatricyclo[4.3.1.13,8]undec-4-ene 3-B which was used in the next step without further purification.

Aufarbeitung

  1. temperaturethe reaction was heated
  2. temperatureat reflux for 20 min
  3. customafter which time all volatiles were removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f4452dc3a9414858b90eaa30610000e8
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026264B2

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