HCID 86625622, Verbindung → Stavudine

HRID 913265

Reaktionsgleichung

Reaktionsgleichung von HRID 913265
[CH3:1][C:2]1[C:8](=[O:9])[NH:7][C:5](=[O:6])[N:4]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[CH:12]=[CH:11]2)[CH:3]=1.CN1C(=O)N(C)CCC1>O>[C@@H:10]1([N:4]2[CH:3]=[C:2]([CH3:1])[C:8](=[O:9])[NH:7][C:5]2=[O:6])[O:14][C@H:13]([CH2:15][OH:16])[CH:12]=[CH:11]1

Komponenten

3

Edukt 1

HCID 86625622HCID 86625622, Verbindung

Produkt 1

HCID 18283StavudineAusbeute 66,82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
2.5 °C

Versuchsvorschrift

Stavudine DMPU solvate (20 g, 0.057 mole) is dissolved in water (20 ml) at 55° C. and the solution is allowed cooling on its own for an hour to crystallize. The mixture is further cooled on 0-5° C. for 2 hrs. The precipitated product is filtered, washed with acetone and dried to give 8.5 g (66.82%) of pure white crystalline Stavudine. HPLC results are given in Table-2

Aufarbeitung

  1. temperaturethe solution is allowed cooling on its own for an hour
  2. customto crystallize
  3. filtrationThe precipitated product is filtered
  4. washwashed with acetone
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c22b27eb05fb4b52934752f5d42be106
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08026356B2

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