Diflunisal → 2',4'-Difluoro-4-hydroxy-5-iodo-1,1'-biphenyl-3-carboxylic acid

HRID 915610Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 915610
C1C(=O)N([I:8])C(=O)C1.[CH:9]1[C:14]([C:15]2[CH:16]=[CH:17][C:18]([F:22])=[CH:19][C:20]=2[F:21])=[CH:13][C:12]([C:23]([OH:25])=[O:24])=[C:11]([OH:26])[CH:10]=1.FC(F)(F)C(O)=O>C(#N)C>[F:21][C:20]1[CH:19]=[C:18]([F:22])[CH:17]=[CH:16][C:15]=1[C:14]1[CH:13]=[C:12]([C:23]([OH:25])=[O:24])[C:11]([OH:26])=[C:10]([I:8])[CH:9]=1

Komponenten

5

Edukt 3

HCID 3059DiflunisalHCID 6422Trifluoroacetic acidHCID 120273N-Iodosuccinimide

Produkt 1

HCID 43695632',4'-Difluoro-4-hydroxy-5-iodo-1,1'-biphenyl-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

198 mg (0.88 mmol, 1.1 eq) of NIS was added at room temperature to a solution of 200 mg (0.8 mmol) of diflunisal in 4 ml of acetonitrile and a catalytic quantity of 18 μl (0.24 mmol, 0.3 eq) of trifluoroacetic acid. It was stirred continuously. The solvent was evaporated at low pressure, it was diluted with dichloromethane and the product was then worked up as in example 1.

Aufarbeitung

  1. customThe solvent was evaporated at low pressure, it
  2. additionwas diluted with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-fcc2cca221fa4cc59de07469d05413a2
Quelldatensatz
uspto-grants-2007_09
Patentnummer
US07265245B2

Notizen zur Reaktion

Wird geladen…