Piconol → 2-Methylthio-4-(3-chloro-4-methoxybenzylamino)-5-(2-pyridylmethoxycarbonyl)pyrimidine

HRID 917592Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 917592
[CH3:1][S:2][C:3]1[N:8]=[C:7]([NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([Cl:19])[CH:12]=2)[C:6]([C:20]([OH:22])=[O:21])=[CH:5][N:4]=1.ClC1C=C(Cl)C=C(Cl)C=1C(Cl)=O.CN(C1C=CC=CN=1)C.[N:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[CH2:50]O>O1CCCC1.O.C(OCC)(=O)C.C(N(CC)CC)C>[CH3:1][S:2][C:3]1[N:8]=[C:7]([NH:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([Cl:19])[CH:12]=2)[C:6]([C:20]([O:22][CH2:50][C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][N:44]=2)=[O:21])=[CH:5][N:4]=1

Komponenten

9

Edukt 4

HCID 11474PiconolHCID 218852-DimethylaminopyridineHCID 27337032,4,6-Trichlorobenzoyl chlorideHCID 226655724-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid

Produkt 1

HCID 178483432-Methylthio-4-(3-chloro-4-methoxybenzylamino)-5-(2-pyridylmethoxycarbonyl)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 8471TriethylamineLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 2-methylthio-4-(3-chloro-4-methoxybenzylamino)-5-carboxypyrimidine (prepared in Example 79) 0.100 g and triethylamine 82 μl in tetrahydrofuran 2.0 ml is treated under room temperature with 2,4,6-trichlorobenzoyl chloride 51 μl and then dimethylaminopyridine about 1 mg is added thereto, followed by stirring for 10 minutes. After addition of 2-pyridinemethanol 31 μl, the mixture is stirred for 12 hours. Ethyl acetate and water are added thereto and the organic layer is separated, washed with sodium hydrogen carbonate solution, brine. The organic layer is dried over anhydrous sodium sulfate and in vacuo. The residue is purified with silica gel chromatography (solvent; chloroform:ethyl acetate=5:1-2:1) and recrystallized from ethyl acetate-isopropyl ether to give 2-methylthio-4-(3-chloro-4-methoxybenzylamino)-5-(2-pyridylmethoxycarbonyl)pyrimidine as a colorless needle, 0.5183 g. mp 117-118° C.

Aufarbeitung

  1. stirringthe mixture is stirred for 12 hours
  2. customthe organic layer is separated
  3. washwashed with sodium hydrogen carbonate solution, brine
  4. dry with materialThe organic layer is dried over anhydrous sodium sulfate and in vacuo
  5. customThe residue is purified with silica gel chromatography (solvent; chloroform:ethyl acetate=5:1-2:1)
  6. customrecrystallized from ethyl acetate-isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-47a282a30901414e910330766c98f36f
Quelldatensatz
uspto-grants-2007_09
Patentnummer
US07273868B2

Notizen zur Reaktion

Wird geladen…