Toluene → 2,4,6-Trimethyl-nicotinoyl-acetone

HRID 918064Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 918064
[C:1]([C:4]1[C:5]([CH3:12])=[N:6][C:7]([CH3:11])=[CH:8][C:9]=1[CH3:10])(=[O:3])[CH3:2].C1(C)C=CC=CC=1.[C:20](OCC)(=[O:22])[CH3:21]>C(O)(=O)C>[CH3:12][C:5]1[N:6]=[C:7]([CH3:11])[CH:8]=[C:9]([CH3:10])[C:4]=1[C:1]([CH2:2][C:20](=[O:22])[CH3:21])=[O:3]

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 8857Ethyl AcetateHCID 2681241-(2,4,6-Trimethylpyridin-3-yl)ethan-1-one

Produkt 1

HCID 537711252,4,6-Trimethyl-nicotinoyl-acetoneAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 172.0 g of 3-acetyl-collidine, 4.5 l of anhydrous toluene, 195 g of ethyl acetate and 282.5 g of potassium tert.-butylate is heated at 100° for 4 hours under nitrogen. The reaction mixture is cooled and poured into 1/2 l of ice water and 140 ml of acetic acid, and the phases are separated and worked up in the customary manner to give 186.1 g of 2,4,6-trimethyl-nicotinoyl-acetone ##SPC8##

Aufarbeitung

  1. temperatureis heated at 100° for 4 hours under nitrogen
  2. temperatureThe reaction mixture is cooled
  3. customthe phases are separated

Quellen und Nachweise

ORD-Eintrag
ord-6c881ff38ad5451ca864df52c054bf45
Quelldatensatz
uspto-grants-1976_07
Patentnummer
US03969363

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