Hydrochloric Acid → N-{2-[(Oxan-2-yl)oxy]ethyl}urea

HRID 918399Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 918399
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][NH2:10].[N-:11]=[C:12]=[O:13].[K+].Cl>O>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][NH:10][C:12]([NH2:11])=[O:13]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 10820667HCID 10820667, VerbindungHCID 11051572Potassio isocyanate

Produkt 1

HCID 12850116N-{2-[(Oxan-2-yl)oxy]ethyl}ureaAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 33.2 g of 2-(tetrahydropyran-2-yloxy)-ethylamine, 50 g of ice, and a solution of 35 g of potassium isocyanate in 80 ml of water is stirred well as 45.6 ml of 5N hydrochloric acid (cooled to -40°C) is added in one portion. The resulting solution is refluxed for 90 minutes, cooled, and extracted with four 150 ml portions of chloroform. The chloroform extract is dried and evaporated in vacuo to give 39.6 g of oil.

Aufarbeitung

  1. additionis added in one portion
  2. temperatureThe resulting solution is refluxed for 90 minutes
  3. temperaturecooled
  4. extractionextracted with four 150 ml portions of chloroform
  5. extractionThe chloroform extract
  6. customis dried
  7. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7828550b1b0d474f977a719cfd8fcfa3
Quelldatensatz
uspto-grants-1976_07
Patentnummer
US03971773

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