2-Methyl-2-thiopseudourea sulfate → Guanidine Sulfate (1:1)

HRID 918424

Reaktionsgleichung

Reaktionsgleichung von HRID 918424
ClC1C(CSCCN)=[N:4]C=CC=1.[S:13]([OH:17])([OH:16])(=[O:15])=[O:14].CS[C:20](=[NH:22])[NH2:21]>O>[S:13]([OH:17])([OH:16])(=[O:15])=[O:14].[NH2:21][C:20]([NH2:22])=[NH:4]

Komponenten

4

Edukt 2

HCID 752702-Methyl-2-thiopseudourea sulfateHCID 129515322-(3-Chloropyrid-2-ylmethylthio)ethylamine

Produkt 1

HCID 499987Guanidine Sulfate (1:1)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 3-chloro-2-((2-aminoethyl)thiomethyl) pyridine (22.4 g) and S-methylisothiourea sulphate (15.1 g) in water (100 ml) was heated under reflux for 3 hours. Concentration, acidification with sulphuric acid and dilution with ethanol afforded 2-[3-chloro-2-pyridyl)methylthio)ethyl]guanidine sulphate.

Aufarbeitung

  1. temperatureunder reflux for 3 hours
  2. concentrationConcentration, acidification with sulphuric acid and dilution with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-38d538664abd48e3b581076a6522e159
Quelldatensatz
uspto-grants-1976_07
Patentnummer
US03971786

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