Maleimide → 3-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dione

HRID 918896

Reaktionsgleichung

Reaktionsgleichung von HRID 918896
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[C:11]1(=[O:17])[NH:15][C:14](=[O:16])[CH:13]=[CH:12]1>C(O)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:13]1[CH2:12][C:11](=[O:17])[NH:15][C:14]1=[O:16]

Komponenten

4

Edukt 2

HCID 10935MaleimideHCID 119785-Methylindole

Produkt 1

HCID 670364713-(5-methyl-1H-indol-3-yl)pyrrolidine-2,5-dioneAusbeute 40,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

5-Methyl indole (10 g, 76 mmol) and maleimide (7.4 g, 76 mmol) in 77 mL of glacial acetic acid was heated at 90° C. for 24 h. The reaction mixture was cooled to RT, and the acetic acid was evaporated under reduced pressure. The residue was suspended in diethyl ether and filtered to obtain solid product (7 g).

Aufarbeitung

  1. customthe acetic acid was evaporated under reduced pressure
  2. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-e263406efc4e4511a115f4c8388cbe6a
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09271971B2

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