Hydrazine hydrate (1:1) → 7-(pyridin-4-yl)thieno[3,2-d]pyridazin-4(5H)-one

HRID 920902Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 920902
[C:1]([C:9]1[S:10][CH:11]=[CH:12][C:13]=1[C:14]([O:16]CC)=O)(=O)[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[NH2:19][NH2:20].O>CCO>[N:5]1[CH:6]=[CH:7][C:2]([C:1]2[C:9]3[S:10][CH:11]=[CH:12][C:13]=3[C:14](=[O:16])[NH:19][N:20]=2)=[CH:3][CH:4]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 86683117Ethyl 2-isonicotinoylthiophene-3-carboxylate

Produkt 1

HCID 866831187-(pyridin-4-yl)thieno[3,2-d]pyridazin-4(5H)-oneAusbeute 85,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The mixture of ethyl 2-isonicotinoylthiophene-3-carboxylate (200 mg, 0.77 mmol) from example 2.2 in NH2NH2.H2O (2 mL) and EtOH (10 mL) was stirred at room temperature for 30 min. The mixture was filtered and the solid dried to obtain the title compound (150 mg, 85.1% yield).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customthe solid dried

Quellen und Nachweise

ORD-Eintrag
ord-1486e61f12834859b396a2cbe561b3cc
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09273068B2

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