Morpholine → 3-Morpholinothieno[3,2-c]pyridin-4(5H)-one

HRID 920930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 920930
Br[C:2]1[C:6]2[C:7](=[O:11])[NH:8][CH:9]=[CH:10][C:5]=2[S:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[O:15]1[CH2:16][CH2:17][N:12]([C:2]2[C:6]3[C:7](=[O:11])[NH:8][CH:9]=[CH:10][C:5]=3[S:4][CH:3]=2)[CH2:13][CH2:14]1

Komponenten

3

Edukt 2

HCID 8083MorpholineHCID 184507963-Bromothieno[3,2-c]pyridin-4(5H)-one

Produkt 1

HCID 866831433-Morpholinothieno[3,2-c]pyridin-4(5H)-oneAusbeute 42,7 %

Versuchsvorschrift

3-Bromothieno[3,2-c]pyridin-4(5H)-one from Example 202.3 (411 mg, 1.786 mmol) and morpholine 81501 mg, 17.23 mmol) were stirred in a microwave for 3 h at 220° C. The mixture was poured onto water and extracted with DCM. The organic phase was concentrated and the residue was recrystallized from EA to give 180 mg (yield: 42.6%) of the title compound.

Aufarbeitung

  1. additionThe mixture was poured onto water
  2. extractionextracted with DCM
  3. concentrationThe organic phase was concentrated
  4. customthe residue was recrystallized from EA

Quellen und Nachweise

ORD-Eintrag
ord-7c7cf88901ce4d718efbd8decd9bb8f8
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09273068B2

Notizen zur Reaktion

Wird geladen…